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Exosome therapy.

Exosomes are tiny particles released by cells, sold by clinics as a cell-free alternative to stem cells for skin, hair and joints. No exosome product is approved by any regulator,[1] and the evidence in people is thin and mostly cosmetic.[2]

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Written by Eli McGarvie.

Clinics that offer exosomes.

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All 8 clinics
ClinicUsed forAlso offersPrice from
Longevity Medical InstituteSan José del Cabo, Mexico KneeShoulderHipBack pain MesenchymalIVInjections USD 1,750 Regeneris TherapyCancún, Mexico KneeBack painHair lossFace MesenchymalIVInjections Not disclosed CellsClinicSan Pedro Garza García, Mexico ArthritisMS MesenchymalUmbilical cord Not disclosed AuragensPanama City, Panama KneeShoulderHipBack pain Umbilical cordMesenchymalIVInjections USD 14,500 BioGenesis Regenerative CenterPanama City, Panama ArthritisMSDiabetesKidney Umbilical cordMesenchymalIV USD 12,000 BioXcelleratorMedellín, Colombia AutismMSArthritisKnee Umbilical cordMesenchymalIVInjections Not disclosed

Exosomes cost.

The lowest price clinics publish in each country.

Full cost guide
MexicoFromUSD 1,7503 clinicsPanamaFromUSD 12,0002 clinicsColombiaFromUSD 1,3992 clinicsThailandFromNot published1 clinic

What is exosome therapy?

Exosome therapy is a treatment that applies or injects particles released by stem cells, instead of the cells themselves. An exosome is a few hundred times smaller than a cell, wrapped in a membrane and unable to copy itself.[3]

What clinics sell as "exosomes" is usually the liquid that stem cells were grown in, filtered or purified to some degree.[3][4] One vial can be close to a protein soup; another can be a cleaner preparation. The label rarely tells you which.

Because there are no living cells, there is no harvest from your body. The product is made in advance from donor cells.[4]

"Billions of exosomes" on a vial is a particle count, not a dose.[5]

The count includes anything the machine sees, and there is still no agreed test that shows whether a batch works.[6]

How it is given

Face and scalp

Spread over the skin straight after microneedling or laser, or injected into the scalp with fine needles.[7] A session takes under an hour, and the usual after-effect is redness for a day or two.[8]

Joints

A single injection into the joint.[9]

IV drip

Sold for anti-aging and recovery. Only tested in trials for severe lung illness.[10]

What it is sold for

Face and anti-agingThe most common use, usually with microneedlingHair lossScalp injections, often in a course of sessionsKneeA single joint injection

The evidence is thin and mostly cosmetic

About 20%fall in wrinkle severity across skin studies, but nearly all had no comparison groupPooled review, 26 skin studies[2]
Could not tellIn the one blinded trial of a stem cell cream, assessors could not tell the treated half of the face from the untreated halfSplit-face controlled trial[11]
No betterthan a placebo injection in the only placebo-controlled knee trialPlacental extracellular vesicles, single knee injection[9]
0 of 28patients who described their treatment online saw a certificate or batch sheet for their vialOur review of patient accounts on Reddit and forums[12]

Exosomes vs PRP

For the face, they came out even. In the one blinded head-to-head trial, each given with microneedling, both improved wrinkles, colour and texture by the same amount, and skin samples showed the same collagen gain on both sides.[13]

For hair, no trial has compared them directly. Indirect comparisons put PRP slightly ahead.[14]

The practical difference is the source. PRP is made from your own blood in the clinic, in front of you. An exosome vial comes from a donor and a lab you usually cannot check.[4][13] PRP vs stem cells

Side effects come mostly from injecting it

On the skin after microneedling, the reported side effects are redness and mild irritation.[8] Injected, published cases include lumps under the skin with permanent scarring,[15] tissue death in both cheeks,[16] and an allergic reaction after a scalp injection.[17] In 2019 the FDA warned the public after serious reactions in patients given unapproved exosome products.[1]

Questions to ask a clinic

  1. What cells were the exosomes made from, and which lab made them?
  2. Can I see the certificate for this batch, including sterility?
  3. The label gives a particle count. How much protein is in the vial?
  4. Is it applied to the skin or injected?
  5. Is it sold as a stem cell treatment? There are no living cells in it.

Sources

19 references
  1. U.S. Food and Drug Administration. Public safety notification on exosome products, 2019. Link
  2. Stack ER, et al. Clinical advances in exosome-based therapies for aesthetic medicine: a systematic review and meta-analysis. Aesthetic Surgery Journal, 2026. Link
  3. Welsh JA, et al. Minimal information for studies of extracellular vesicles (MISEV2023). Journal of Extracellular Vesicles, 2024. Link
  4. Asadpour A, et al. Uncovering the gray zone: mapping the global landscape of direct-to-consumer businesses offering interventions based on secretomes, extracellular vesicles and exosomes. Stem Cell Research & Therapy, 2023. Link
  5. Gupta D, et al. Dosing extracellular vesicles. Advanced Drug Delivery Reviews, 2021. Link
  6. Witwer KW, et al. Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications. Journal of Extracellular Vesicles, 2019. Link
  7. Park GH, et al. Efficacy of combined treatment with human adipose tissue stem cell-derived exosome-containing solution and microneedling. Journal of Cosmetic Dermatology, 2023. Link
  8. Jafarzadeh A, et al. Effectiveness of regenerative medicine for skin lightening and rejuvenation: a systematic review of extracellular vesicles and conditioned media. Stem Cell Research & Therapy, 2025. Link
  9. Bolandnazar NS, et al. Safety and efficacy of placental mesenchymal stromal cells-derived extracellular vesicles in knee osteoarthritis. BMC Musculoskeletal Disorders, 2024. Link
  10. Lightner AL, et al. Bone marrow mesenchymal stem cell-derived extracellular vesicle infusion for the treatment of respiratory failure from COVID-19. Chest, 2023. Link
  11. Alhaddad M, et al. Red deer umbilical cord lining mesenchymal stem cell extract cream for rejuvenation of the face. Journal of Drugs in Dermatology, 2019. Link
  12. StemFinder review of first-hand patient accounts on Reddit and patient forums, 2026. Method
  13. Estupiñan B, et al. Adipose mesenchymal stem cell-derived exosomes versus platelet-rich plasma for photoaged facial skin: an investigator-blinded, split-face trial. Journal of Cosmetic Dermatology, 2025. Link
  14. Chien WY, et al. Stem cell-derived conditioned medium for alopecia: a systematic review and meta-analysis. Journal of Plastic, Reconstructive & Aesthetic Surgery, 2024. Link
  15. Park KY, et al. Adverse reactions following intradermal injection of exosome-based formulations: a case series. Journal of Cosmetic Dermatology, 2025. Link
  16. AlBargawi S, et al. Necrosis following dermal injection of lyophilized exosomes: a case report. Journal of Cosmetic Dermatology, 2025. Link
  17. Zhuang J, et al. Treatment of anaphylaxis after injection of stem cell exosomes. Journal of Craniofacial Surgery, 2023. Link
  18. National Pharmaceutical Regulatory Agency. Guidelines for registration of cell and gene therapy products in Malaysia, 2nd edition, 2025. Link
  19. COFEPRIS. La COFEPRIS suspendió clínica del D.F. que ofrecía tratamientos con células madre sin aval científico, 2015. Link

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